Vol. 6, Issue 5 (2020)
A clinico-microbiological profile, antimicrobial sensitivity and outcome of neonatal sepsis in NICU, Ajmer
Author(s): Dhrmendar Rawat, Pawan kumar Barolia, Daya Lal Solanki, Hemlata Bakolia
Abstract: Background: Neonatal septicaemia is a clinical entity that is characterized by systemic signs and symptoms of infection and accompanied by bacteraemia in first 4 weeks of life and is one of the four leading causes of neonatal mortality and morbidity in India. Aim: To determine the bacterial spectrum and antimicrobial susceptibility pattern of neonatal septicaemia in a tertiary care hospital of Jaipur, Rajasthan. Materials and Methods: In this prospective observational study, 346 blood samples were collected over period of 6 months and processed from clinically suspected neonates according to standard laboratory protocol. Antimicrobial susceptibility of the isolates was done by Kirby Bauer disc diffusion method according to Clinical and laboratory standard institution (CLSI) recommendations. Results: Blood culture reports were positive in 53 (15.31%) cases. Commonest clinical presentation of neonates with septicemia was respiratory distress and Commonest maternal risk factor was PROM >18 hours. Gram negative septicaemia (55.10%) was encountered more than Gram positive (44.90%). Coagulase negative Staphylococci (38.78%) was the predominant isolate followed by, Klebsiella spp in 34.69% cases. Best overall sensitivity among Gram-negative isolates was to polymyxin B, colistin and meropenem (100%). Gram-positive isolates had highest sensitivity to Linezolid (100 %) and Vancomycin (100%). Conclusion: Gram negative organisms are the leading cause of neonatal septicaemia with Klebsiella spp being commonest. Coagulase negative Staphylococci is the predominant isolate among Gram positive organisms. Most of the isolates are resistant to common antibiotics.